Meno-PAUSE Hormone, Weight, Health, and Mind Optimization Menopause, Low Energy and ThinningHair"Doc, since I became menopausal, my energy levels are a fraction of what they used to be, and my hair is thinning. Is this just part of menopause?" A reader of this newsletter, I’ll call Susan, scheduled a phone consultation with me last week. She complained of low energy, and thinning hair. She stated her symptoms, and the conversation went silent. After a while, I got the hint. I said, "Nancy, those are classic hypothyroidism symptoms." "But my doctor tested my thyroid and said it was normal." I shook my head. Let me first explain to all of you about the HPT axis. It’s the cascading pathway in which thyroid hormones are made. HYPOTHALAMUS The hypothalamus is a specialized portion of our brain that works like a hormone thermostat. When it sees that you need more thyroid hormones, it releases a hormone called Thyroid Releasing Hormone, otherwise known as TRH. PITUITARY GLAND TRH signals the pituitary gland that the body needs more thyroid hormones. This Master Gland then releases Thyroid Stimulating Hormone, otherwise known as TSH. THYROID GLAND TSH signals the thyroid gland to release the thyroid hormones, primarily a hormone called thyroxine or T4. TSH IS THE THYROID HORMONE DOCTORS USE Doctors uses a test that measures the amount of TSH you have in your body to determine if your thyroid is functioning properly. If there is more than "normal", you are diagnosed as being hypothyroid. If there is less than "normal," you are diagnosed as being hyperthyroid. “Susan, your doctor most likely said your thyroid was ‘normal’ because your TSH test was in the normal range for the American population.” "NORMAL" TSH A normal TSH test means that the measured amount of TSH falls in the middle 95th percentile of American women. That means that 95% of American Women are considered normal. Did you just hear me cough while I said BullShit? That means those who fall in the lowest or highest 2.5% are considered abnormal. Those that fall in the highest 2.5% are diagnosed as hypothyroid, and those in the bottom 2.5% are diagnosed as hyperthyroid. T4 VS. T3 The problem is that TSH is released by the pituitary gland when T4 is low, but T4 is a weak thyroid hormone. Most thyroid specialists look at T4 as a pro-hormone, meaning it needs to become another hormone to be effective. T4 is an amino acid called tyrosine with four iodine molecules attached to it. To be activated, one of the iodine molecules needs to be cleaved from the tyrosine. T3 is the hormone that creates energy (ATP) within the cell. MENOPAUSAL INDUCED HYPOTHYROISM Menopausal hypothyroidism is caused by the lack of T3. After menopause, several hormonal and metabolic shifts occur: 1. Estrogen Drops, and So Does T4-to-T3 Conversion Estrogen helps sensitize liver enzymes (especially deiodinase type I) that convert T4 (thyroxine) into T3 (triiodothyronine), the active thyroid hormone. When estrogen decreases, causing a woman not to ovulate, (Menopause) conversion of T4 to T3 slows — meaning you may have plenty of T4, keeping TSH in the "normal" range, but not enough T3. 2. Cortisol increases during menopause Menopause can crank up stress/cortisol. I define stress as elevated cortisol. Elevated cortisol signals the production of another thyroid hormone called reverse T3. rT3 attaches the T3 receptor sites blocking T3. rT3 protects the body from overload caused by stress. 3. Liver and Gut function decrease during menopause About 20% of T4-to-T3 conversion happens in the gut, and most of the rest in the liver. Menopause often slows bile flow, gut motility, and microbiome diversity. If the liver and gut function slow, your T3 production follows suit. 4. Reduced Progesterone during menopause causes less thyroid receptor sensitivity. Progesterone doesn’t just balance estrogen; it also enhances thyroid receptor responsiveness. When progesterone drops, the receptors become less sensitive to T3. Even if you have “normal” lab values, your cells may be ignoring T3’s message — classic “menopausal hypothyroidism.” 5. Menopause causes a decline in muscle mass T3 is your metabolic spark plug. When lean muscle mass drops after menopause, your body downshifts thyroid output because it senses less metabolic demand. It’s a “use it or lose it” hormone economy. MENOPAUSAL INDUCED HAIR LOSS We all know that T3 is the precursor to energy, but what does it have to do with “pretty hair”? 1. T3 = The Follicle Foreman T3 regulates cellular energy (ATP) inside hair follicle cells. Hair growth is one of the body’s most energy-demanding processes — it’s constantly dividing, keratinizing, and building protein. When T3 is low, The body basically says: “We’re in energy-saving mode — hair growth is non-essential right now.” Hair shifts from the anagen (growth) phase into telogen (resting) phase, leading to diffuse hair shedding. 2. T3 Turns On Keratin GenesT3 literally activates the genes that produce keratin (the protein making up hair, skin, and nails). "Think of T3 as the “on switch” for your hair factory — when it’s off, production halts." 3. Reduced Blood Flow = Starving the FollicleThyroid hormones increase nitric oxide and vascular endothelial growth factor (VEGF) — big words meaning they boost microcirculation. "When T3 is low, scalp blood flow decreases. Less oxygen, less nutrition = starving follicles." 4. T3 and Stem CellsT3 interacts with dermal papilla cells, which tell stem cells in the follicle when to grow new hair. When T3 drops, those papillae stop signaling, so new hair cycles get delayed or skipped altogether. "That’s why menopausal hypothyroid hair loss feels slow and frustrating — the follicles are lazy, not dead." 5. Hormone CrossfireLow T3 doesn’t act alone — it throws off estrogen, progesterone, and DHT metabolism. "DHT, or dihydrotestosterone, is a hormone produced by both men and women that can cause hair follicle shrinkage and thinning in women with a genetic predisposition, particularly during times of lower estrogen, such as menopause."
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Low T3 can reduce sex hormone–binding globulin (SHBG), freeing up more DHT, which can further miniaturize follicles causing the perfect storm: low growth signals and high DHT halt new hair growth. Vicky not only dropped dropped her menopausal weight but stopped her hair loss— her rebalanced hormones not only reset her metabolism, they kept her hair nice and thick. Want to see what rebalanced hormones can do for you? Click Here and I will explain how to optimize your hormoens,w weight, health and life in one phone call. Take advantage of my forty-five years of practice experience with thousands of patients, to optimize energy and thwart hair loss. AND IT'S ALL FREE! I've been retired for ten years. This is not my job, it's my mission. I will coach you dialy for a week for free to make sure you understand everything you will need to do. Since I only accept referrals and my roster is currently full, I can only take 2 new free week clients — if you’ve been waiting to reset your metabolism before the holidays, now’s the time. Click below 👇🏼 👉 [Click Here to Schedule Your Free Consultation] Are you on Facebook? THIS WEEK'S USIE Here's another Us-ie of us as we travel the world teaching how to optimize hormones, weight, health and minds. Eye of London Vicky and I are catching the views high above London while riding the Eye of London. Optimize your life by optimizing your hormones, weight, health, and life, with HOPE. 🏴 The Macs Hormone and Weight Optimization Author and Coaches HOPE isn’t just a feeling. It’s a protocol—and it’s waiting for you. 💖 P.S. The sooner we talk, the sooner you’ll feel like you again. Disclaimer: The information provided in this newsletter is for educational purposes only and is not intended as medical advice. Always consult with your healthcare provider before starting any new supplement, including zinc, especially if you have a medical condition, are pregnant, or are taking medications. Individual needs may vary; this content does not replace the advice of a professional medical expert. © 2025 Doc Mac Coaching. All rights reserved. |
I have practiced hormone and weight optimization for over forty-five years. I retired 10 years ago; at least, that is what I thought. When I retired, my wife and I owned and operated several medical clinics specializing in hormone and weight optimization. We discovered that as a woman enters menopause, her hormones become disrupted, causing many women to gain weight rapidly, and no matter what they do, not be able to lose it. If that has happened to you, text me at 209-345-9799. I have found that those who text me are serious about creating the body they desire. Once I receive your text, I will find a convenient time for you to speak with me. During our conversation, I will customize a gourmet weight loss menu for you, and tweak it until it works. Our menus have no caloric restrictions or frequency of meals. There is no charge! 👍 Doc
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